The greatest battle lies within.
The seemingly invincible Spider-Man goes up against an all-new crop of villains—including the shape-shifting Sandman. While Spider-Man’s superpowers are altered by an alien organism, his alter ego, Peter Parker, deals with nemesis Eddie Brock and also gets caught up in a love triangle.
Tobey MaguireSpider-Man / Peter Parker
Kirsten DunstMary Jane Watson
James FrancoNew Goblin / Harry Osborn
Thomas Haden ChurchSandman / Flint Marko
Topher GraceVenom / Eddie Brock
Bryce Dallas HowardGwen Stacy
Rosemary HarrisMay Parker
J.K. SimmonsJ. Jonah Jameson
James CromwellCaptain Stacy
Dylan BakerDr. Curt Connors
Theresa RussellEmma Marko
Bill NunnJoseph 'Robbie' Robertson
Bruce CampbellMaître D'
Elizabeth BanksMiss Brant
Ted RaimiHoffman
